Non-invasive measurement of oxygen metabolism. Part 1: Historical review and state of the art

Oxygen metabolism is a key factor in the life of living organism. The article first part review methods for measuring oxygen metabolism. Purpose. aim this to present an insight into evolution way from global local measurement brain perfusion. role 15 O isotope as “gold standard” using positron emission tomography (PET) described. We also provide case report tumor perfusion measurements our clinic. Materials and methods. More than 200 Pubmed publications were studied with keywords “positron + O-15”. Relevant that do not contain these or them different wording analyzed. A clinical CT perfusion, MR-ASL PET H 2 provided. Results. extraction, metabolism, 50 papers are cited depicting advances technologies. Examples use fundamental research practice given. Conclusion. obvious value oxygen-isotope data combined invasiveness (in some cases), technical complexity high cost procedure. second will be devoted alternative which developing 21st century intended wide use.